Aging and Your Genes

Aging and Your Genes


By Jean-Marc Sobczyk MD, ND

Glutathione is the most important anti-oxidant available in the body. Glutathione helps preventing oxidation/damage done to the cells and the DNA, combatting oxidative stress and free radicals.

Oxidative stress and free radicals are the result of various processed including daily exposure to toxins (environmental pollutants, pesticides in food, water, heavy metals in food and in our environment, cigarette smoke and many other sources)

Glutathione supports optimal cells function and prevents the growth of abnormal cells. It contributes to a healthy metabolism.

Glutathione is created from 3 amino acids: Glutamine, Glycine, Cysteine. It comes in limited amount from food, mostly synthesized in our liver.  

As we get older our body’s ability to make glutathione decreases.

Genetic predispositions can also affect glutathione synthesis and can lead to early aging.

What are the top 4 genes to prevent aging

  • MTHFR is most researched gene. It helps the body make methyl folate. This active form of folate supports directly DNA repair, providing a constant supply of DNA Bases (needed by chromosomes) to create and repair our cells.  It also supports Homocysteine metabolism.
  • Maintaining optimal level of homocysteine (between 5 to 7.5) ensures that the body has enough glutathione available. Too little or too much homocysteine is a sign telling us our body is dealing with excessive inflammation or is not able to keep the inflammation under control and not able to clear the toxins the body is exposed to.
  • CBS enzyme (Cystathionine Beta Synthase) is also a critical enzyme preventing the cells to age too quickly.  This enzyme needs vitamin B6 and Vitamin D to function and to initiate the conversion of Homocysteine into Glutathione
  • GSPT1 and SOD2 are 2 other important genes coding for enzyme helping the body using  glutathione to reduce oxidative stress and free radicals and preventing further damage to our DNA and cells.

How to support Glutathione synthesis?

  • A diet rich in folates and vitamin B12, vitamin B6 and choline will support the MTHFR and CBS enzyme function
  • Selenium and Vitamin C will support GSPT1 and SOD function.
  • Herbs supporting healthy level of glutathione includes Milk Thistle, Turmeric.
  • Whey protein can also support glutathione level, providing a good amount of Cysteine one of the three amino-acids needed.
  • If you have an MTHFR mutation you should also take a “methylation support” supplement.

If you are interested in knowing more about your genetic predispositions and learning how to optimize your health and preserve glutathione levels, you can schedule an appointment with Dr. Jean-Marc Sobczyk, MD ND, MTHFR Expert to discuss the best strategies to help you slow down the natural aging process, stay mentally sharp and stay energized. He is available at the Akasha Center for Integrative Medicine, call today 310-451-8880 to schedule.

Dr. Jean-Marc Sobczyk MD, ND is a licensed Naturopathic Doctor in the state of California, MD trained in France. Follow him on Instagram @mthfr_expert and @drjeanmarc!



Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.



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